Modification of β-Defensin-2 by Dicarbonyls Methylglyoxal and Glyoxal Inhibits Antibacterial and Chemotactic Function In Vitro

BACKGROUND: Beta-defensins (hBDs) provide antimicrobial and chemotactic defense against bacterial, viral and fungal infections. Human β-defensin-2 (hBD-2) acts against gram-negative bacteria and chemoattracts immature dendritic cells, thus regulating innate and adaptive immunity. Immunosuppression d...

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Detalles Bibliográficos
Autores principales: Kiselar, Janna G., Wang, Xiaowei, Dubyak, George R., El Sanadi, Caroline, Ghosh, Santosh K., Lundberg, Kathleen, Williams, Wesley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526640/
https://www.ncbi.nlm.nih.gov/pubmed/26244639
http://dx.doi.org/10.1371/journal.pone.0130533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526640/
https://www.ncbi.nlm.nih.gov/pubmed/26244639
http://dx.doi.org/10.1371/journal.pone.0130533

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