Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)

Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating pre-mRNA splicing events through the extensive phosphorylation of splicing factors from the family...

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Detalles Bibliográficos
Autores principales: Siqueira, Raoni Pais, Barbosa, Éverton de Almeida Alves, Polêto, Marcelo Depólo, Righetto, Germanna Lima, Seraphim, Thiago Vargas, Salgado, Rafael Locatelli, Ferreira, Joana Gasperazzo, Barros, Marcus Vinícius de Andrade, de Oliveira, Leandro Licursi, Laranjeira, Angelo Brunelli Albertoni, Almeida, Márcia Rogéria, Júnior, Abelardo Silva, Fietto, Juliana Lopes Rangel, Kobarg, Jörg, de Oliveira, Eduardo Basílio, Teixeira, Robson Ricardo, Borges, Júlio César, Yunes, Jose Andrés, Bressan, Gustavo Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526641/
https://www.ncbi.nlm.nih.gov/pubmed/26244849
http://dx.doi.org/10.1371/journal.pone.0134882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526641/
https://www.ncbi.nlm.nih.gov/pubmed/26244849
http://dx.doi.org/10.1371/journal.pone.0134882

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