Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver

MicroRNAs (miRNAs) are important regulators and potential therapeutic targets of metabolic disease. In this study we show by in vivo administration of locked nucleic acid (LNA) inhibitors that suppression of endogenous miR-29 lowers plasma cholesterol levels by ~40%, commensurate with the effect of...

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Detalles Bibliográficos
Autores principales: Kurtz, C. Lisa, Fannin, Emily E., Toth, Cynthia L., Pearson, Daniel S., Vickers, Kasey C., Sethupathy, Praveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526858/
https://www.ncbi.nlm.nih.gov/pubmed/26246194
http://dx.doi.org/10.1038/srep12911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526858/
https://www.ncbi.nlm.nih.gov/pubmed/26246194
http://dx.doi.org/10.1038/srep12911

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