Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors

GlgE is a bacterial maltosyltransferase that catalyzes the elongation of a cytosolic, branched α-glucan. In Mycobacterium tuberculosis (M. tb), inactivation of GlgE (Mtb GlgE) results in the rapid death of the organism due to a toxic accumulation of the maltosyl donor, maltose-1-phosphate (M1P), sug...

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Detalles Bibliográficos
Autores principales: Lindenberger, Jared J., Kumar Veleti, Sri, Wilson, Brittney N., Sucheck, Steven J., Ronning, Donald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526890/
https://www.ncbi.nlm.nih.gov/pubmed/26245983
http://dx.doi.org/10.1038/srep12830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526890/
https://www.ncbi.nlm.nih.gov/pubmed/26245983
http://dx.doi.org/10.1038/srep12830

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