Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives

BACKGROUND: Streptomyces filipinensis is the industrial producer of filipin, a pentaene macrolide, archetype of non-glycosylated polyenes, and widely used for the detection and the quantitation of cholesterol in biological membranes and as a tool for the diagnosis of Niemann–Pick type C disease. Gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Payero, Tamara D, Vicente, Cláudia M, Rumbero, Ángel, Barreales, Eva G, Santos-Aberturas, Javier, de Pedro, Antonio, Aparicio, Jesús F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527110/
https://www.ncbi.nlm.nih.gov/pubmed/26246267
http://dx.doi.org/10.1186/s12934-015-0307-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527110/
https://www.ncbi.nlm.nih.gov/pubmed/26246267
http://dx.doi.org/10.1186/s12934-015-0307-4

Ejemplares similares