CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner

Transforming growth factor-β1 (TGF-β1) plays an important role in the pathogenesis and progression of chronic kidney disease. Connective tissue growth factor (CTGF) is a critical fibrogenic mediator of TGF-β1. Mammalian sirtuin 1 (Sirt1) is reported to attenuate renal fibrosis by inhibiting the TGF-...

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Detalles Bibliográficos
Autores principales: Ren, Yunzhuo, Du, Chunyang, Yan, Li, Wei, Jingying, Wu, Haijiang, Shi, Yonghong, Duan, Huijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527372/
https://www.ncbi.nlm.nih.gov/pubmed/26257513
http://dx.doi.org/10.2147/DDDT.S86748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527372/
https://www.ncbi.nlm.nih.gov/pubmed/26257513
http://dx.doi.org/10.2147/DDDT.S86748

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