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CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner

Transforming growth factor-β1 (TGF-β1) plays an important role in the pathogenesis and progression of chronic kidney disease. Connective tissue growth factor (CTGF) is a critical fibrogenic mediator of TGF-β1. Mammalian sirtuin 1 (Sirt1) is reported to attenuate renal fibrosis by inhibiting the TGF-...

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Detalles Bibliográficos
Autores principales:	Ren, Yunzhuo, Du, Chunyang, Yan, Li, Wei, Jingying, Wu, Haijiang, Shi, Yonghong, Duan, Huijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527372/ https://www.ncbi.nlm.nih.gov/pubmed/26257513 http://dx.doi.org/10.2147/DDDT.S86748

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