Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by conducting different omics data analyses, we demonstrated that cisplatin induces cell death in a proximal tubular cell line by suppressing glycolysis- and tricarboxylic acid (TCA)/mitochondria-related gene...

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Detalles Bibliográficos
Autores principales: Choi, Yong-Min, Kim, Han-Kyul, Shim, Wooyoung, Anwar, Muhammad Ayaz, Kwon, Ji-Woong, Kwon, Hyuk-Kwon, Kim, Hyung Joong, Jeong, Hyobin, Kim, Hwan Myung, Hwang, Daehee, Kim, Hyung Sik, Choi, Sangdun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527592/
https://www.ncbi.nlm.nih.gov/pubmed/26247588
http://dx.doi.org/10.1371/journal.pone.0135083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527592/
https://www.ncbi.nlm.nih.gov/pubmed/26247588
http://dx.doi.org/10.1371/journal.pone.0135083

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