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Coordinated Evolution of Influenza A Surface Proteins

The surface proteins hemagglutinin (HA) and neuraminidase (NA) of human influenza A virus evolve under selection pressures to escape adaptive immune responses and antiviral drug treatments. In addition to these external selection pressures, some mutations in HA are known to affect the adaptive lands...

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Detalles Bibliográficos
Autores principales: Neverov, Alexey D., Kryazhimskiy, Sergey, Plotkin, Joshua B., Bazykin, Georgii A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527594/
https://www.ncbi.nlm.nih.gov/pubmed/26247472
http://dx.doi.org/10.1371/journal.pgen.1005404