AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high as 270 μg/ml were...

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Detalles Bibliográficos
Autores principales: Fuchs, Sebastian P., Martinez-Navio, José M., Piatak, Michael, Lifson, Jeffrey D., Gao, Guangping, Desrosiers, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527674/
https://www.ncbi.nlm.nih.gov/pubmed/26248318
http://dx.doi.org/10.1371/journal.ppat.1005090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527674/
https://www.ncbi.nlm.nih.gov/pubmed/26248318
http://dx.doi.org/10.1371/journal.ppat.1005090

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