Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

Huntington’s Disease (HD) is caused by inheritance of a single disease-length allele harboring an expanded CAG repeat, which continues to expand in somatic tissues with age. The inherited disease allele expresses a toxic protein, and whether further somatic expansion adds to toxicity is unknown. We...

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Detalles Bibliográficos
Autores principales: Budworth, Helen, Harris, Faye R., Williams, Paul, Lee, Do Yup, Holt, Amy, Pahnke, Jens, Szczesny, Bartosz, Acevedo-Torres, Karina, Ayala-Peña, Sylvette, McMurray, Cynthia T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527696/
https://www.ncbi.nlm.nih.gov/pubmed/26247199
http://dx.doi.org/10.1371/journal.pgen.1005267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527696/
https://www.ncbi.nlm.nih.gov/pubmed/26247199
http://dx.doi.org/10.1371/journal.pgen.1005267

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