Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma

BACKGROUND: The majority of chordomas show activation of the platelet-derived growth factor receptor (PDGFR). Based on in vitro intertumoral variation in response to recombinant PDGF protein and PDGFR inhibition, and variable tumor response to imatinib, we hypothesized that chordomas resistant to PD...

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Detalles Bibliográficos
Autores principales: Lee, Dae-Hee, Zhang, Ying, Kassam, Amin B., Park, Myung-Jin, Gardner, Paul, Prevedello, Daniel, Henry, Stephanie, Horbinski, Craig, Beumer, Jan H., Tawbi, Hussein, Williams, Brian J., Shaffrey, Mark E., Egorin, Merrill J., Abounader, Roger, Park, Deric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527706/
https://www.ncbi.nlm.nih.gov/pubmed/26247786
http://dx.doi.org/10.1371/journal.pone.0134426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527706/
https://www.ncbi.nlm.nih.gov/pubmed/26247786
http://dx.doi.org/10.1371/journal.pone.0134426

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