SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes its interacting partner protein LRPPRC by protecting it from degradation. Although SLIRP is completely dependent on LRPPRC for its stability, reduced levels of LRPPRC...

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Detalles Bibliográficos
Autores principales: Lagouge, Marie, Mourier, Arnaud, Lee, Hyun Ju, Spåhr, Henrik, Wai, Timothy, Kukat, Christian, Silva Ramos, Eduardo, Motori, Elisa, Busch, Jakob D., Siira, Stefan, Kremmer, Elisabeth, Filipovska, Aleksandra, Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527767/
https://www.ncbi.nlm.nih.gov/pubmed/26247782
http://dx.doi.org/10.1371/journal.pgen.1005423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527767/
https://www.ncbi.nlm.nih.gov/pubmed/26247782
http://dx.doi.org/10.1371/journal.pgen.1005423

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