The Evolution of the Secreted Regulatory Protein Progranulin

Progranulin is a secreted growth factor that is active in tumorigenesis, wound repair, and inflammation. Haploinsufficiency of the human progranulin gene, GRN, causes frontotemporal dementia. Progranulins are composed of chains of cysteine-rich granulin modules. Modules may be released from progranu...

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Detalles Bibliográficos
Autores principales: Palfree, Roger G. E., Bennett, Hugh P. J., Bateman, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527844/
https://www.ncbi.nlm.nih.gov/pubmed/26248158
http://dx.doi.org/10.1371/journal.pone.0133749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527844/
https://www.ncbi.nlm.nih.gov/pubmed/26248158
http://dx.doi.org/10.1371/journal.pone.0133749

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