DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

DNMT1 is recruited by PCNA and UHRF1 to maintain DNA methylation after replication. UHRF1 recognizes hemimethylated DNA substrates via the SRA domain, but also repressive H3K9me3 histone marks with its TTD. With systematic mutagenesis and functional assays, we could show that chromatin binding furth...

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Detalles Bibliográficos
Autores principales: Qin, Weihua, Wolf, Patricia, Liu, Nan, Link, Stephanie, Smets, Martha, Mastra, Federica La, Forné, Ignasi, Pichler, Garwin, Hörl, David, Fellinger, Karin, Spada, Fabio, Bonapace, Ian Marc, Imhof, Axel, Harz, Hartmann, Leonhardt, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528052/
https://www.ncbi.nlm.nih.gov/pubmed/26065575
http://dx.doi.org/10.1038/cr.2015.72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528052/
https://www.ncbi.nlm.nih.gov/pubmed/26065575
http://dx.doi.org/10.1038/cr.2015.72

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