Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction

Dysregulation of ribosome biogenesis causes human diseases, such as Diamond-Blackfan anemia, del (5q-) syndrome and bone marrow failure. However, the mechanisms of blood disorders in these diseases remain elusive. Through genetic mapping, molecular cloning and mechanism characterization of the zebra...

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Detalles Bibliográficos
Autores principales: Jia, Xiao-E, Ma, Ke, Xu, Tao, Gao, Lei, Wu, Shuang, Fu, Cong, Zhang, Wenjuan, Wang, Zhizhang, Liu, Kaiyu, Dong, Mei, Jing, Changbin, Ren, Chunguang, Dong, Zhiwei, Chen, Yi, Jin, Yi, Huang, Qiuhua, Chang, Xing, Deng, Min, Li, Li, Luo, Lingfei, Zhu, Jun, Dang, Yongjun, Chang, Hung-Chun, Zon, Leonard I, Zhou, Yi, Chen, Saijuan, Pan, Weijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528055/
https://www.ncbi.nlm.nih.gov/pubmed/26138676
http://dx.doi.org/10.1038/cr.2015.81

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