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An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells

Hepatocytes are critical for the maintenance of liver homeostasis, but its involvement in hepatic fibrogenesis remains elusive. Hepatocyte nuclear factor 1α (HNF1α) is a liver-enriched transcription factor that plays a key role in hepatocyte function. Our previous study revealed a significant inhibi...

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Detalles Bibliográficos
Autores principales: Qian, Hui, Deng, Xing, Huang, Zhao-Wei, Wei, Ji, Ding, Chen-Hong, Feng, Ren-Xin, Zeng, Xin, Chen, Yue-Xiang, Ding, Jin, Qiu, Lei, Hu, Zhen-Lin, Zhang, Xin, Wang, Hong-Yang, Zhang, Jun-Ping, Xie, Wei-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528057/
https://www.ncbi.nlm.nih.gov/pubmed/26169608
http://dx.doi.org/10.1038/cr.2015.84