Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

ß-amyloid (Aß(1−42)) is produced by proteolytic cleavage of the transmembrane type-1 protein, amyloid precursor protein. Under pathological conditions, Aß(1−42)self-aggregates into oligomers, which cause synaptic dysfunction and neuronal loss, and are considered the culprit of Alzheimer's disea...

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Detalles Bibliográficos
Autores principales: Giuffrida, Maria L., Tomasello, Marianna F., Pandini, Giuseppe, Caraci, Filippo, Battaglia, Giuseppe, Busceti, Carla, Di Pietro, Paola, Pappalardo, Giuseppe, Attanasio, Francesco, Chiechio, Santina, Bagnoli, Silvia, Nacmias, Benedetta, Sorbi, Sandro, Vigneri, Riccardo, Rizzarelli, Enrico, Nicoletti, Ferdinando, Copani, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528168/
https://www.ncbi.nlm.nih.gov/pubmed/26300732
http://dx.doi.org/10.3389/fncel.2015.00297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528168/
https://www.ncbi.nlm.nih.gov/pubmed/26300732
http://dx.doi.org/10.3389/fncel.2015.00297

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