Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis

BACKGROUND: Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP). While the large-scale mitochondrial release of pro-apoptotic proteins activat...

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Detalles Bibliográficos
Autores principales: Choe, Sehyo Charley, Hamacher-Brady, Anne, Brady, Nathan Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528699/
https://www.ncbi.nlm.nih.gov/pubmed/26253153
http://dx.doi.org/10.1186/s12964-015-0115-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528699/
https://www.ncbi.nlm.nih.gov/pubmed/26253153
http://dx.doi.org/10.1186/s12964-015-0115-9

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