Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson–Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot’s syndromes. Although genetic testing for these mutations is available, robust cla...

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Detalles Bibliográficos
Autores principales: Wu, Hong, Zeng, Hong, Lam, Robert, Tempel, Wolfram, Kerr, Iain D., Min, Jinrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528928/
https://www.ncbi.nlm.nih.gov/pubmed/26249686
http://dx.doi.org/10.1107/S2053230X15010183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528928/
https://www.ncbi.nlm.nih.gov/pubmed/26249686
http://dx.doi.org/10.1107/S2053230X15010183

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