Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form

Bacterial infections remain a serious health concern, in particular causing life-threatening infections of hospitalized and immunocompromised patients. The situation is exacerbated by the rise in antibacterial drug resistance, and new treatments are urgently sought. In this endeavour, accurate struc...

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Detalles Bibliográficos
Autores principales: Baum, Bernhard, Lecker, Laura S. M., Zoltner, Martin, Jaenicke, Elmar, Schnell, Robert, Hunter, William N., Brenk, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528935/
https://www.ncbi.nlm.nih.gov/pubmed/26249693
http://dx.doi.org/10.1107/S2053230X15010614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528935/
https://www.ncbi.nlm.nih.gov/pubmed/26249693
http://dx.doi.org/10.1107/S2053230X15010614

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