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Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phosphorylation sites (substrates) of active kinases a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529189/ https://www.ncbi.nlm.nih.gov/pubmed/26252020 http://dx.doi.org/10.1371/journal.pcbi.1004403 |