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TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms
Fibroblasts are major cellular components of the breast cancer stroma, and influence the growth, survival and invasion of epithelial cells. Compared to normal tissue fibroblasts, carcinoma associated fibroblasts (CAFs) show increased expression of numerous soluble factors including growth factors an...
Autores principales: | Fang, Wei Bin, Mafuvadze, Benford, Yao, Min, Zou, An, Portsche, Mike, Cheng, Nikki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529193/ https://www.ncbi.nlm.nih.gov/pubmed/26252654 http://dx.doi.org/10.1371/journal.pone.0135063 |
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