Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies

The cyclin-dependent kinase 4 (CDK4)-cyclin D1 complex plays a crucial role in the transition from the G1 phase to S phase of the cell cycle. Among the CDKs, CDK4 is one of the genes most frequently affected by somatic genetic variations that are associated with various forms of cancer. Thus, becaus...

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Detalles Bibliográficos
Autores principales: N, Nagasundaram, Zhu, Hailong, Liu, Jiming, V, Karthick, C, George Priya Doss, Chakraborty, Chiranjib, Chen, Luonan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529227/
https://www.ncbi.nlm.nih.gov/pubmed/26252490
http://dx.doi.org/10.1371/journal.pone.0133969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529227/
https://www.ncbi.nlm.nih.gov/pubmed/26252490
http://dx.doi.org/10.1371/journal.pone.0133969

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