High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells

The cystine-glutamate antiporter (system x(c) (-)) is a Na(+)-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intracellular glutathione synthesis via cystine u...

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Detalles Bibliográficos
Autores principales: Thomas, Ajit G., Sattler, Rita, Tendyke, Karen, Loiacono, Kara A., Hansen, Hans, Sahni, Vishal, Hashizume, Yutaka, Rojas, Camilo, Slusher, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529246/
https://www.ncbi.nlm.nih.gov/pubmed/26252954
http://dx.doi.org/10.1371/journal.pone.0127785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529246/
https://www.ncbi.nlm.nih.gov/pubmed/26252954
http://dx.doi.org/10.1371/journal.pone.0127785

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