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Clinical potential of vorapaxar in cardiovascular risk reduction in patients with atherosclerosis
Vorapaxar (ZONTIVITY™, formerly known as SCH 530348) is a specific, orally active antagonist of the protease-activated receptor-1 (PAR-1) on platelets. It inhibits thrombin-induced platelet activation by binding to the ectodomain of PAR-1. After animal studies and Phase II studies showed that vorapa...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529257/ https://www.ncbi.nlm.nih.gov/pubmed/26346960 http://dx.doi.org/10.2147/TCRM.S55469 |