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Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction

The combination of radiotherapy with sunitinib is clinically hampered by rare but severe side effects and varying results with respect to clinical benefit. We studied different scheduling regimes and dose reduction in sunitinib and radiotherapy in preclinical tumor models to improve potential outcom...

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Detalles Bibliográficos
Autores principales: Kleibeuker, Esther A, ten Hooven, Matthijs A, Castricum, Kitty C, Honeywell, Richard, Griffioen, Arjan W, Verheul, Henk M, Slotman, Ben J, Thijssen, Victor L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529339/
https://www.ncbi.nlm.nih.gov/pubmed/25828633
http://dx.doi.org/10.1002/cam4.441