Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

Nicotinamide N-methyltransferase (Nnmt) methylates nicotinamide, a form of vitamin B3, to produce N1-methylnicotinamide (MNAM). Nnmt is an emerging metabolic regulator in adipocytes but its role in the liver, a tissue with the strongest Nnmt expression, is not known. In spite of its overall high exp...

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Detalles Bibliográficos
Autores principales: Hong, Shangyu, Moreno-Navarrete, Jose M, Wei, Xiaojing, Kikukawa, Yusuke, Tzameli, Iphigenia, Prasad, Deepthi, Lee, Yoonjin, Asara, John M, Fernandez-Real, Jose Manuel, Maratos-Flier, Eleftheria, Pissios, Pavlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529375/
https://www.ncbi.nlm.nih.gov/pubmed/26168293
http://dx.doi.org/10.1038/nm.3882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529375/
https://www.ncbi.nlm.nih.gov/pubmed/26168293
http://dx.doi.org/10.1038/nm.3882

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