GC-Rich Extracellular DNA Induces Oxidative Stress, Double-Strand DNA Breaks, and DNA Damage Response in Human Adipose-Derived Mesenchymal Stem Cells

Background. Cell free DNA (cfDNA) circulates throughout the bloodstream of both healthy people and patients with various diseases. CfDNA is substantially enriched in its GC-content as compared with human genomic DNA. Principal Findings. Exposure of haMSCs to GC-DNA induces short-term oxidative stres...

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Detalles Bibliográficos
Autores principales: Kostyuk, Svetlana, Smirnova, Tatiana, Kameneva, Larisa, Porokhovnik, Lev, Speranskij, Anatolij, Ershova, Elizaveta, Stukalov, Sergey, Izevskaya, Vera, Veiko, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529983/
https://www.ncbi.nlm.nih.gov/pubmed/26273425
http://dx.doi.org/10.1155/2015/782123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529983/
https://www.ncbi.nlm.nih.gov/pubmed/26273425
http://dx.doi.org/10.1155/2015/782123

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