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Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

Analysis of brain ultrastructure using electron microscopy typically relies on chemical fixation. However, this is known to cause significant tissue distortion including a reduction in the extracellular space. Cryo fixation is thought to give a truer representation of biological structures, and here...

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Detalles Bibliográficos
Autores principales: Korogod, Natalya, Petersen, Carl CH, Knott, Graham W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530226/
https://www.ncbi.nlm.nih.gov/pubmed/26259873
http://dx.doi.org/10.7554/eLife.05793