Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse

[Image: see text] A gain-of-function mutation (T635A) in the transient receptor potential (TRP) channel TRPC3 results in abnormal channel gating and causes cerebellar ataxia in the dominant Moonwalker (Mwk) mouse mutant. However, the underlying molecular and structural mechanisms are unclear. Here,...

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Detalles Bibliográficos
Autores principales: Hanson, Sonya M., Sansom, Mark S. P., Becker, Esther B. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530436/
https://www.ncbi.nlm.nih.gov/pubmed/26112884
http://dx.doi.org/10.1021/acs.biochem.5b00235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530436/
https://www.ncbi.nlm.nih.gov/pubmed/26112884
http://dx.doi.org/10.1021/acs.biochem.5b00235

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