S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation

Cigarette smoke induces injury and neutrophilic inflammation in the airways of smokers. The stability and activity of inflammatory effectors, IL8 and neutrophil elastase (NE), can be prolonged by binding to airway heparan sulfate (HS)/syndecan-1, posing risk for developing chronic obstructive pulmon...

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Detalles Bibliográficos
Autores principales: Lam, David CL, Chan, Stanley CH, Mak, Judith CW, Freeman, Craig, Ip, Mary SM, Shum, Daisy KY
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530444/
https://www.ncbi.nlm.nih.gov/pubmed/26256047
http://dx.doi.org/10.1038/srep12945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530444/
https://www.ncbi.nlm.nih.gov/pubmed/26256047
http://dx.doi.org/10.1038/srep12945

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