Cargando…

STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer

The importance of store-operated Ca(2+) entry (SOCE) and the role of its key molecular regulators, STIM1 and ORAI1, in the development of cancer are emerging. Here, we report an unexpected dual function of SOCE in prostate cancer progression by revealing a decrease in the expression of STIM1 in huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yingxi, Zhang, Shu, Niu, Haiying, Ye, Yujie, Hu, Fen, Chen, Si, Li, Xuefei, Luo, Xiaohe, Jiang, Shan, Liu, Yanhua, Chen, Yanan, Li, Junying, Xiang, Rong, Li, Na
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530453/ https://www.ncbi.nlm.nih.gov/pubmed/26257076 http://dx.doi.org/10.1038/srep11754

Ejemplares similares

Local H(2) release remodels senescence microenvironment for improved repair of injured bone
por: Chen, Shengqiang, et al.
Publicado: (2023)

STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment
por: Frisch, Janina, et al.
Publicado: (2019)

Sacral neuromodulation for overactive bladder using the InterStim and BetterStim systems
por: Meng, Lingfeng, et al.
Publicado: (2022)

sTim-3 alleviates liver injury via regulation of the immunity microenvironment and autophagy
por: Yang, Ying, et al.
Publicado: (2020)

STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression
por: Wang, Jian, et al.
Publicado: (2019)

SOX2 Gene Regulates the Transcriptional Network of Oncogenes and Affects Tumorigenesis of Human Lung Cancer Cells
por: Chen, Si, et al.
Publicado: (2012)

Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines
por: Zheng, Sisi, et al.
Publicado: (2018)

Mesenchymal Stem Cells Accelerate the Remodeling of Bladder VX2 Tumor Interstitial Microenvironment by TGFβ1-Smad Pathway
por: Yang, Qingya, et al.
Publicado: (2019)

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers
por: Li, Xin, et al.
Publicado: (2017)

STIM1-dependent Ca(2+) microdomains are required for myofilament remodeling and signaling in the heart
por: Parks, Cory, et al.
Publicado: (2016)

STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma
por: Johnson, Martin T., et al.
Publicado: (2021)

Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments
por: Tang, Xiaoqiang, et al.
Publicado: (2020)

STIM1L traps and gates Orai1 channels without remodeling the cortical ER
por: Saüc, Sophie, et al.
Publicado: (2015)

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
por: Yu, Tao, et al.
Publicado: (2023)

STIM1 Knockout Enhances PDGF-Mediated Ca(2+) Signaling through Upregulation of the PDGFR–PLCγ–STIM2 Cascade
por: Huang, Tzu-Yu, et al.
Publicado: (2018)

Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation
por: Sogkas, Georgios, et al.
Publicado: (2015)

Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia
por: Lu, Yifei, et al.
Publicado: (2018)

Mesenchymal stromal cells in tumor microenvironment remodeling of BCR-ABL negative myeloproliferative diseases
por: La Spina, Enrico, et al.
Publicado: (2023)

Single-cell melanoma transcriptomes depicting functional versatility and clinical implications of STIM1 in the tumor microenvironment
por: Wong, Henry Sung-Ching, et al.
Publicado: (2021)

Elevated expression of STIM1 is involved in lung tumorigenesis
por: Wang, Yadong, et al.
Publicado: (2016)

Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway
por: Niu, Haiying, et al.
Publicado: (2017)

A pH probe inhibits senescence in mesenchymal stem cells
por: Wang, Lihong, et al.
Publicado: (2018)

Mesenchymal Stem Cells in Inflammation Microenvironment Accelerates Hepatocellular Carcinoma Metastasis by Inducing Epithelial-Mesenchymal Transition
por: Jing, Yingying, et al.
Publicado: (2012)

STIM1 strengthens clotting
por: Bashyam, Hema
Publicado: (2008)

The regulation of STIM1 by phosphorylation
por: Pozo-Guisado, Eulalia, et al.
Publicado: (2013)

Role of STIM1 in neurodegeneration
por: Pascual-Caro, Carlos, et al.
Publicado: (2018)

The many states of STIM1
por: Fahrner, Marc, et al.
Publicado: (2021)

Developing senescence to remodel the embryo
por: Storer, Mekayla, et al.
Publicado: (2014)

STIM1 in tumor cell death: angel or devil?
por: Ren, Ran, et al.
Publicado: (2023)

Differential Roles for STIM1 and STIM2 in Store-Operated Calcium Entry in Rat Neurons
por: Gruszczynska-Biegala, Joanna, et al.
Publicado: (2011)

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia
por: Fleur-Lominy, Shella Saint, et al.
Publicado: (2018)

Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice
por: Li, Ming, et al.
Publicado: (2016)

Senescence and Immunoregulation in the Tumor Microenvironment
por: Ruhland, Megan K., et al.
Publicado: (2021)

Cellular senescence and the tumour microenvironment
por: Takasugi, Masaki, et al.
Publicado: (2022)

Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis
por: Yu, Fang, et al.
Publicado: (2019)

Deficient for endoplasmic reticulum calcium sensors Stim1 and Stim2 affects aberrant antibody affinity maturation in B cells
por: Mao, Xuhua, et al.
Publicado: (2016)

Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice
por: Lv, Ya-Jie, et al.
Publicado: (2018)

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
por: Chen, Hsuan-An, et al.
Publicado: (2023)

ATP depletion induces translocation of STIM1 to puncta and formation of STIM1–ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP
por: Chvanov, Michael, et al.
Publicado: (2008)

Role of microRNAs in remodeling the tumor microenvironment (Review)
por: Pan, Zhaoji, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s60158euqfbeev1fkk2ntpiqp9