DNA sequencing with MspA: Molecular Dynamics simulations reveal free-energy differences between sequencing and non-sequencing mutants

MspA has been identified as a promising candidate protein as a component of a nanopore-based DNA-sequencing device. However the wildtype protein must be engineered to incorporate all of the features desirable for an accurate and efficient device. In the present study we have utilized atomistic molec...

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Detalles Bibliográficos
Autores principales: Manara, Richard M.A., Jayne Wallace, E., Khalid, Syma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530457/
https://www.ncbi.nlm.nih.gov/pubmed/26255609
http://dx.doi.org/10.1038/srep12783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530457/
https://www.ncbi.nlm.nih.gov/pubmed/26255609
http://dx.doi.org/10.1038/srep12783

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