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Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large...

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Detalles Bibliográficos
Autores principales: Yuchi, Zhiguang, Yuen, Siobhan M. Wong King, Lau, Kelvin, Underhill, Ainsley Q., Cornea, Razvan L., Fessenden, James D., Van Petegem, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530471/
https://www.ncbi.nlm.nih.gov/pubmed/26245150
http://dx.doi.org/10.1038/ncomms8947