Structural basis for retroviral integration into nucleosomes

Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome(1,2). How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foa...

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Detalles Bibliográficos
Autores principales: Maskell, Daniel P., Renault, Ludovic, Serrao, Erik, Lesbats, Paul, Matadeen, Rishi, Hare, Stephen, Lindemann, Dirk, Engelman, Alan N., Costa, Alessandro, Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530500/
https://www.ncbi.nlm.nih.gov/pubmed/26061770
http://dx.doi.org/10.1038/nature14495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530500/
https://www.ncbi.nlm.nih.gov/pubmed/26061770
http://dx.doi.org/10.1038/nature14495

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