Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

Alzheimer’s disease (AD) is a severe(1) age-related neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neur...

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Detalles Bibliográficos
Autores principales: Gjoneska, Elizabeta, Pfenning, Andreas R., Mathys, Hansruedi, Quon, Gerald, Kundaje, Anshul, Tsai, Li-Huei, Kellis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530583/
https://www.ncbi.nlm.nih.gov/pubmed/25693568
http://dx.doi.org/10.1038/nature14252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530583/
https://www.ncbi.nlm.nih.gov/pubmed/25693568
http://dx.doi.org/10.1038/nature14252

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