NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics

Dengue genome encodes a two component protease complex (NS2B-NS3pro) essential for the viral maturation/infectivity, thus representing a key drug target. Previously, due to its “complete insolubility”, the isolated NS3pro could not be experimentally studied and it remains elusive what structure it a...

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Detalles Bibliográficos
Autores principales: Gupta, Garvita, Lim, Liangzhong, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530887/
https://www.ncbi.nlm.nih.gov/pubmed/26258523
http://dx.doi.org/10.1371/journal.pone.0134823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530887/
https://www.ncbi.nlm.nih.gov/pubmed/26258523
http://dx.doi.org/10.1371/journal.pone.0134823

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