pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

In this study, a novel pH-responsive cholesterol-PEG adduct-coated solid lipid nanoparticles (C-PEG-SLNs) carrying doxorubicin (DOX) capable of overcoming multidrug resistance (MDR) breast cancer cells is presented. The DOX-loaded SLNs have a mean hydrodynamic diameter of ~100 nm and a low polydispe...

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Detalles Bibliográficos
Autores principales: Chen, Hsin-Hung, Huang, Wen-Chia, Chiang, Wen-Hsuan, Liu, Te-I, Shen, Ming-Yin, Hsu, Yuan-Hung, Lin, Sung-Chyr, Chiu, Hsin-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531030/
https://www.ncbi.nlm.nih.gov/pubmed/26346762
http://dx.doi.org/10.2147/IJN.S86053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531030/
https://www.ncbi.nlm.nih.gov/pubmed/26346762
http://dx.doi.org/10.2147/IJN.S86053

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