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pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

In this study, a novel pH-responsive cholesterol-PEG adduct-coated solid lipid nanoparticles (C-PEG-SLNs) carrying doxorubicin (DOX) capable of overcoming multidrug resistance (MDR) breast cancer cells is presented. The DOX-loaded SLNs have a mean hydrodynamic diameter of ~100 nm and a low polydispe...

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Detalles Bibliográficos
Autores principales:	Chen, Hsin-Hung, Huang, Wen-Chia, Chiang, Wen-Hsuan, Liu, Te-I, Shen, Ming-Yin, Hsu, Yuan-Hung, Lin, Sung-Chyr, Chiu, Hsin-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531030/ https://www.ncbi.nlm.nih.gov/pubmed/26346762 http://dx.doi.org/10.2147/IJN.S86053

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