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The life-extending effect of dietary restriction requires Foxo3 in mice

Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/–)) and homozygous ((–/–)) mice were subje...

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Detalles Bibliográficos
Autores principales: Shimokawa, Isao, Komatsu, Toshimitsu, Hayashi, Nobutaka, Kim, Sang-Eun, Kawata, Takuya, Park, Seongjoon, Hayashi, Hiroko, Yamaza, Haruyoshi, Chiba, Takuya, Mori, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531086/
https://www.ncbi.nlm.nih.gov/pubmed/25808402
http://dx.doi.org/10.1111/acel.12340