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Intersecting transcription networks constrain gene regulatory evolution
Epistasis—the non-additive interactions between different genetic loci—constrains evolutionary pathways, blocking some and permitting others(1–8). For biological networks such as transcription circuits, the nature of these constraints and their consequences are largely unknown. Here we describe the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531262/ https://www.ncbi.nlm.nih.gov/pubmed/26153861 http://dx.doi.org/10.1038/nature14613 |