COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex

BACKGROUND: Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochemical mechanisms. The rate of neddylation and its extent are regulated by 2 oppo...

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Detalles Bibliográficos
Autores principales: Bornstein, Gil, Grossman, Chagai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531434/
https://www.ncbi.nlm.nih.gov/pubmed/26265931
http://dx.doi.org/10.1186/s13008-015-0011-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531434/
https://www.ncbi.nlm.nih.gov/pubmed/26265931
http://dx.doi.org/10.1186/s13008-015-0011-0

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