Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**

A Rh-catalyst system based on the asymmetric ligand (t)Bu(2)PCH(2)P(o-C(6)H(4)OMe)(2) is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group.

Detalles Bibliográficos
Autores principales: Prades, Amparo, Fernández, Maitane, Pike, Sebastian D, Willis, Michael C, Weller, Andrew S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531818/
https://www.ncbi.nlm.nih.gov/pubmed/26069052
http://dx.doi.org/10.1002/anie.201503208
Descripción
Sumario:A Rh-catalyst system based on the asymmetric ligand (t)Bu(2)PCH(2)P(o-C(6)H(4)OMe)(2) is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group.

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