Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**

A Rh-catalyst system based on the asymmetric ligand (t)Bu(2)PCH(2)P(o-C(6)H(4)OMe)(2) is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group.

Detalles Bibliográficos
Autores principales: Prades, Amparo, Fernández, Maitane, Pike, Sebastian D, Willis, Michael C, Weller, Andrew S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531818/
https://www.ncbi.nlm.nih.gov/pubmed/26069052
http://dx.doi.org/10.1002/anie.201503208
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author Prades, Amparo
Fernández, Maitane
Pike, Sebastian D
Willis, Michael C
Weller, Andrew S
author_facet Prades, Amparo
Fernández, Maitane
Pike, Sebastian D
Willis, Michael C
Weller, Andrew S
author_sort Prades, Amparo
collection PubMed
description A Rh-catalyst system based on the asymmetric ligand (t)Bu(2)PCH(2)P(o-C(6)H(4)OMe)(2) is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group.
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spelling pubmed-45318182015-08-15 Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes** Prades, Amparo Fernández, Maitane Pike, Sebastian D Willis, Michael C Weller, Andrew S Angew Chem Int Ed Engl Communications A Rh-catalyst system based on the asymmetric ligand (t)Bu(2)PCH(2)P(o-C(6)H(4)OMe)(2) is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group. WILEY-VCH Verlag 2015-07-13 2015-06-09 /pmc/articles/PMC4531818/ /pubmed/26069052 http://dx.doi.org/10.1002/anie.201503208 Text en © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Prades, Amparo
Fernández, Maitane
Pike, Sebastian D
Willis, Michael C
Weller, Andrew S
Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**
title Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**
title_full Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**
title_fullStr Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**
title_full_unstemmed Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**
title_short Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes**
title_sort well-defined and robust rhodium catalysts for the hydroacylation of terminal and internal alkenes**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531818/
https://www.ncbi.nlm.nih.gov/pubmed/26069052
http://dx.doi.org/10.1002/anie.201503208
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