Protective Effect of Chlormethiazole, a Sedative, against Acetaminophen-Induced Liver Injury in Mice

OBJECTIVES: The hepatotoxicity of acetaminophen is not a result of the parent compound but is mediated by its reactive metabolite N-acetyl-p-benzoquinone imine. Cytochrome P4502E1 (CYP2E1) is the principal enzyme of this biotransformation, which accounts for approximately 52% of the bioactivation in...

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Detalles Bibliográficos
Autores principales: Lee, Han Chu, Jung, Sung Ae, Jung, Hye Kyung, Yi, Sun Young, Kim, Doe Young, Moon, Il Hwan, Park, Sung Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Internal Medicine 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531924/
https://www.ncbi.nlm.nih.gov/pubmed/10461422
http://dx.doi.org/10.3904/kjim.1999.14.2.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531924/
https://www.ncbi.nlm.nih.gov/pubmed/10461422
http://dx.doi.org/10.3904/kjim.1999.14.2.27

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