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High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors
BACKGROUND: Obesity is a progressive metabolic disorder in the current world population, and is characterized by the excess deposition of fat in the adipose tissue. Pancreatic lipase is one of the key enzymes in the hydrolysis of triglycerides into monoglycerides and free fatty acids, and is thus co...
Autores principales: | Veeramachaneni, Ganesh Kumar, Raj, K Kranthi, Chalasani, Leela Madhuri, Bondili, Jayakumar Singh, Talluri, Venkateswara Rao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532172/ https://www.ncbi.nlm.nih.gov/pubmed/26273199 http://dx.doi.org/10.2147/DDDT.S84052 |
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