Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ

Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which is necessary for AKT phosphorylation at the S473 and T450 sites, and also for AKT downstream signaling as well. A number of Sin1 splicing variants have been reported that can produce different Sin1 isoforms due to exon skipping or...

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Detalles Bibliográficos
Autores principales: Yuan, Yuanyang, Pan, Bangfen, Sun, Haipeng, Chen, Guoqiang, Su, Bing, Huang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532406/
https://www.ncbi.nlm.nih.gov/pubmed/26263164
http://dx.doi.org/10.1371/journal.pone.0135017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532406/
https://www.ncbi.nlm.nih.gov/pubmed/26263164
http://dx.doi.org/10.1371/journal.pone.0135017

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