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Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation
Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532446/ https://www.ncbi.nlm.nih.gov/pubmed/26262877 http://dx.doi.org/10.1371/journal.pone.0135519 |