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Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients

BACKGROUND: Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebellar and cerebral regions. The motor deficit in these patients may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. However, th...

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Autores principales: Hernandez-Castillo, Carlos R., Galvez, Victor, Mercadillo, Roberto, Diaz, Rosalinda, Campos-Romo, Aurelio, Fernandez-Ruiz, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532454/
https://www.ncbi.nlm.nih.gov/pubmed/26263162
http://dx.doi.org/10.1371/journal.pone.0135449
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author Hernandez-Castillo, Carlos R.
Galvez, Victor
Mercadillo, Roberto
Diaz, Rosalinda
Campos-Romo, Aurelio
Fernandez-Ruiz, Juan
author_facet Hernandez-Castillo, Carlos R.
Galvez, Victor
Mercadillo, Roberto
Diaz, Rosalinda
Campos-Romo, Aurelio
Fernandez-Ruiz, Juan
author_sort Hernandez-Castillo, Carlos R.
collection PubMed
description BACKGROUND: Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebellar and cerebral regions. The motor deficit in these patients may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis of diffusion tensor imaging enables an unbiased whole-brain quantitative comparison of the diffusion proprieties of white matter tracts in vivo. METHODS: Fourteen genetically confirmed SCA2 patients and aged-matched healthy controls participated in the study. Tract-based spatial statistics were performed to analyze structural white matter damage using two different measurements: fractional anisotropy (FA) and mean diffusivity (MD). Significant diffusion differences were correlated with the patient's ataxia impairment. RESULTS: Our analysis revealed decreased FA mainly in the inferior/middle/superior cerebellar peduncles, the bilateral posterior limb of the internal capsule and the bilateral superior corona radiata. Increases in MD were found mainly in cerebellar white matter, medial lemniscus, and middle cerebellar peduncle, among other regions. Clinical impairment measured with the SARA score correlated with FA in superior parietal white matter and bilateral anterior corona radiata. Correlations with MD were found in cerebellar white matter and the middle cerebellar peduncle. CONCLUSION: Our findings show significant correlations between diffusion measurements in key areas affected in SCA2 and measures of motor impairment, suggesting a disruption of information flow between motor and sensory-integration areas. These findings result in a more comprehensive view of the clinical impact of the white matter degeneration in SCA2.
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spelling pubmed-45324542015-08-20 Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients Hernandez-Castillo, Carlos R. Galvez, Victor Mercadillo, Roberto Diaz, Rosalinda Campos-Romo, Aurelio Fernandez-Ruiz, Juan PLoS One Research Article BACKGROUND: Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebellar and cerebral regions. The motor deficit in these patients may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis of diffusion tensor imaging enables an unbiased whole-brain quantitative comparison of the diffusion proprieties of white matter tracts in vivo. METHODS: Fourteen genetically confirmed SCA2 patients and aged-matched healthy controls participated in the study. Tract-based spatial statistics were performed to analyze structural white matter damage using two different measurements: fractional anisotropy (FA) and mean diffusivity (MD). Significant diffusion differences were correlated with the patient's ataxia impairment. RESULTS: Our analysis revealed decreased FA mainly in the inferior/middle/superior cerebellar peduncles, the bilateral posterior limb of the internal capsule and the bilateral superior corona radiata. Increases in MD were found mainly in cerebellar white matter, medial lemniscus, and middle cerebellar peduncle, among other regions. Clinical impairment measured with the SARA score correlated with FA in superior parietal white matter and bilateral anterior corona radiata. Correlations with MD were found in cerebellar white matter and the middle cerebellar peduncle. CONCLUSION: Our findings show significant correlations between diffusion measurements in key areas affected in SCA2 and measures of motor impairment, suggesting a disruption of information flow between motor and sensory-integration areas. These findings result in a more comprehensive view of the clinical impact of the white matter degeneration in SCA2. Public Library of Science 2015-08-11 /pmc/articles/PMC4532454/ /pubmed/26263162 http://dx.doi.org/10.1371/journal.pone.0135449 Text en © 2015 Hernandez-Castillo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hernandez-Castillo, Carlos R.
Galvez, Victor
Mercadillo, Roberto
Diaz, Rosalinda
Campos-Romo, Aurelio
Fernandez-Ruiz, Juan
Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients
title Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients
title_full Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients
title_fullStr Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients
title_full_unstemmed Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients
title_short Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients
title_sort extensive white matter alterations and its correlations with ataxia severity in sca 2 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532454/
https://www.ncbi.nlm.nih.gov/pubmed/26263162
http://dx.doi.org/10.1371/journal.pone.0135449
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